The Rat Anti-CCR9 [7E7] Antibody from MyBioSource.com is a Rat Monoclonal antibody to CC-CKR-9, CCR9, D6, and ACKR2. This antibody recognizes Human, and Mouse antigen. The Rat Anti-CCR9 [7E7] Antibody has been validated for the following applications: Flow Cytometry, Immunocytochemistry, Immunofluorescence, Immunohistochemistry, and Immunohistochemistry - fixed.
Description
The protein encoded by this gene is a member of the beta chemokine receptor family It is predicted to be a seven transmembrane protein similar to G protein coupled receptors Chemokines and their receptors are key regulators of the thymocytes migration and maturation in normal and inflammation conditions This gene is expressed in a range of tissues and hemopoietic cells The expression of this receptor in lymphatic endothelial cells and overexpression in vascular tumors suggested its function in chemokine-driven recirculation of leukocytes and possible chemokine effects on the development and growth of vascular tumors This receptor appears to bind the majority of beta-chemokine family members however its specific function remains unknown The specific ligand of this receptor is CCL25 It has been found that this gene is differentially expressed by T lymphocytes of small intestine and colon suggested a role in the thymocytes recruitment and development that may permit functional specialization of immune responses in different segment of the gastrointestinal tract This gene is mapped to chromosome 3p213 a region that includes a cluster of chemokine receptor genes Two alternatively spliced transcript variants have been described